The Relationship Of Treatment History, Medication Adherence, And Anti-Tuberculosis Drug Side Effects With Drug-Resistant Tuberculosis

Dhimaz Ralina Alghivary; Eka  Hariani

doi:10.63922/ijevss.v5i03.6192

Dhimaz Ralina Alghivary Universitas Muhammadiyah Pontianak
Eka Hariani Universitas Muhammadiyah Pontianak

DOI: https://doi.org/10.63922/ijevss.v5i03.6192

Keywords: adherence to medication, drug-resistant tuberculosis, literature review, side effects of anti-tuberculosis drugs, TB treatment history

Abstract

Drug-resistant tuberculosis (DR-TB) is a major challenge in TB control in Indonesia. This structured narrative review maps evidence on prior treatment history, medication adherence, and adverse effects of anti-tuberculosis drugs (ATD), distinguishing direct evidence on DR-TB from indirect evidence on treatment experience and adherence. A structured search of Google Scholar, Portal Garuda, PubMed, and institutional repositories was conducted for Indonesian- and English-language publications from 2020 to 2026. The initial search identified 668 records; twelve sources were retained in the narrative corpus, while six studies with sufficiently extractable findings are presented in the expanded characteristics table. Reported odds ratios (ORs) for prior treatment history ranged from 2.4 to 8.0 in cited observational studies, but confidence intervals were not consistently available and estimates were not pooled. Evidence linking adverse effects with non-adherence was indirect, and the available material did not establish mediation, temporal sequence, or a universal causal pathway to DR-TB. Acquired and transmitted resistance are discussed separately. The proposed three-factor relationship is retained only as a conceptual synthesis for future prospective research.

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